A version(epsilon4, increases risk up to 12 times) of the APOE gene is associated with alzheimer's.
Sites on a brain protein called tau are linked to alzheimer's, if a tau protein becomes entangled,it can lead to alzheimer's.
Polymorphism called P86L in a gene called CALHMI, in alzheimers' patients,this polymorphism occurs in 40% of such patients, whereas normally the polymorphism occurs in only 20% o the population.
It affects calcium levels in the brain.
The connection is not 100% sure.
Mutation in the PSEN1 and PSEN2 may also be associated with alzheimers'
http://www.alzgene.org/
Pcdh11x variant associated wih alzhimers.
APP mutant;A673V in a homozygous state.
Two copies of a mutation(above?) in APP gene is more likely to lead to Alzheimers'.
Presenilin 1 and 2 are also associated with alzheimers.
Variants of two genes called clusterin(involved in removing rogue proteins) and picalm are associate wih alzheimers.
A variant of the CR1 gene has also been linked with alzheimers.
The ephb2 receptor,a group of tyrosine kinase receptors has been implicated in alzheimer's.
Showing posts with label gene genes alzheimer's apoe brain protein tau polymorphism p86l calhmi 40% calcium mutation psen1 sen2 www.alzgene.org pcdh11x cr1. Show all posts
Showing posts with label gene genes alzheimer's apoe brain protein tau polymorphism p86l calhmi 40% calcium mutation psen1 sen2 www.alzgene.org pcdh11x cr1. Show all posts
Friday, 18 April 2008
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