Friday 8 August 2008

Neanderthal Genome

Analysis of DNA from a 38,000 years old bone found in a cave near Vindija, Croatia, has revealed DNA of 13 genes in mitochondrial DNA , different from that of modern humans,suggesting little or no interbreeding with modern humans.

5.3 gb of  neanderthal dna sequence has been generated.

It is believed that mutations in their mitochondrial DNA might have led to their extinction

The analysis suggests that Neanderthals share a mitochondrial `Eve' about 660,000 year ago when they probably split rom other humans.

They were lactose-intolorant.

The researchers at the Max-Planck Institue have read 4% so far of the neanderthal genome, and hope to complete the whole genome by end of year.

Five neanderthal mitochondrial genomes have been sequenced,the team led by svante paabo at the max planck institue sequenced over 16,000 mitochondrial bases of which only 55 bases only differed among rhe six samples.
It has been calculated that there may have only been only 3,500 breeding female neanderthal at any one time.
Project leader Svante paabo is to announce preliminary results on 12 February 2009.
He says his group will publish a first draft of the genome later this year(2009).

Search Amazon.com for neanderthal genome
Researchers have discovered that up to 4% of non-africans DNA is from neanderthals.
Such genetics exchanges propably took places in the fertile crescent.
One gene discovered is the HLA*0702 which is common in europeans and asians

Researchers have found differences between neanderthals and modern humans in genes concerned with metabolism,skin and skeleton.

Researchers have found an ABO group locus and a taste receptor gene.

Genes possibly originating from interbreeding with neanderthals include:
HLA-A*02-C*07:02,HLA-A*26-C*16:02,HLA-A*66-1602 which has its highest frequencies where the burmese,chinese and indian border meet.
 
HLA-C*1505 possibly may have passed from neanderthals to modern human populations in the area between the nile delta,northern saudi arabia and cicilia in turkey.
(perhaps some of the people mentioned in the bible had this gene).
Also present in about 2-3% of the essaouira-tangiers costal area which was a neanderthal outlier area.

Saturday 2 August 2008

Genes linked to autism

NHE9 mutations have been linked to autism.

NLGN4 gene mutations G995,K378R,R704C and V403M as well as deletions of exons 4,5 and 6 are believed to be linked to autism.

A deletion close to a gene called PCDH10 appears to be liked with autism.

Shank3 deletions has also been linked to autism.

A variant of the MET gene is more common in autistic children, who also have bowel disorders.

SNPs believe to be associate with autism include;
rs10512025
rs12293188
rs13206855
rs16910190
rs16910194
rs17088254
rs2632453
rs3763947
rs4307059
rs4742408
rs4742409
rs6477233
rs7766973
rs7923367
rs952834

Friday 1 August 2008

Genes linked with Crohn's isease

the following genes have been linked.
Atg16l1 t300a
IRGM
nlrp3
NOD2
rs20411
rs745230



Ashkenaz jews have genetic markers for Crohn's disease at the following.
rs2986
rs555920
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Search Amazon.com for nlrp

Genes linked to Graves' disease

A study suggests that a gene called CTLA4 may be linked.
A SNP called CTLA4_-1722_T/C appears to have a strong association with GD.

ICAM-1 and

SELE polymorphisms have been linked to grave disease,polymorphisms like rs3917412

Genes linked to epilepsy

genes associated with a rare form of inherited epilepsy called Action myoclonus-renal failure syndrome, whose sufferers are also affected by kidney failure,include SCARB2 mutations