Sunday 21 September 2008

genes linked to parkinson's Disease

Mutation in a gene called LKKR2 or G2019S has been linked in some studies to Parkinson's Disease.

SNCA has also been linked to parkinson's
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Friday 19 September 2008

Human population genetics in India.

India still has the `out of africa' genetic footprint.

The M2 mitochondrial DNA haplogroup split from the main M haplogroup in India about 50,000 years ago.

About 10% of tribals have this haplogroup.

A study of 132 people from 25 groups, plus 560,000 snps(405 snps from 55 groups).

Nyshi and ao naga respectively tribals in Arunachel pradesh and Nagaland,speakers of a Tibeto-burman language genetically cluster with the chinese..

Those who speak Indo-european or were of higher castes eg brahmin,I presume, tended to cluster with western eurasians.

Saturday 13 September 2008

Genomics Institue at Harvard University receives endowment

The Broad Institue of MIT and Harvard will receive an endowment of $400 million from Eli Broad,an philanthropist, which will create a non-profit organisation.

The institue does things like genome sequencing and genetic disease factors.

Friday 12 September 2008

genes linked to brain cancer

A mutation in a gene called IDH1 appears in gliolastoma suffers who are 20 years younger than normal glioblastoma suffers.
Mutation(s) produce an amino acid substitation at arg132(R132)

Mutations in the following genes have been associated with glioblastoma;EGFR, MLH1,MSH2, MSH6, NF1(mutations e25-1, e29+1, Q1966, R1513 R1391S),PI(3)K, PMS2, TP53 ,

The APC and beta-catenin gene have been implicated in brain cancer.

Park2 has also been associated with glioblastoma

Friday 5 September 2008

CCR5 distribution

A gene variant CCR5-Delta32, so-called because 32 DNA base pairs are missing gives some people some resistance to HIV infection and take longer to develope AIDS.

The variant is in about 15% of people in some northern European areas,whereas less than 4% of Greeks have the variant.

The frequency of the gene variant follows the changing boundaries of the Roman Empire 500BC-500 AD.

One theory is that the Romans brought with them disease-carrying mosquitoes, which reduced CCR5-Delta32 frequency,modern carriers of the variant are more susceptible to West Nile Fever.