Thursday 31 July 2008

Eye colour genes

OCA2 rs1667394
OCA2 rs7495174
TYRP1 polymorphisms have been linked with eye colour.
rs1408799

TYR polymorphism rs1126809

OCA2 on chromosome 15 influences eye colour.
A mutation of about 6-10,000 years ago lead to blue-eyed people.

skin pigment genes

An ASIP polymorphism rs6058017
SLC24A4
SLC24A5,a variant of this gene has been linked to lighter skin colour
tpcn2
Search Amazon.com for skin genetics

genes linked to skin cancer/melanomas

Genes at the following loci are believed to be associated with cutaneous melanomas;
20q11
NRHC
RHC
rs1042602
rs1126809
rs1408799
rs1885120
rs910873


genes at the ollowing loci are believed to be associated with basal cell carcinoma.
20q11
RHC
rs1126809

genes linked to schizophrenia

A gene called ZNF804A increases the risk of schizophrenia by 1%.

The following genes are believed to possily be associated with schizophrenia.
(it appears to be very dificult to pinpoint which genes are involved)

APOE 2/3/4
cit
drd1 rs4532
DTNBP1 rs1011313
erbb4
MTHFR rs1801131
NOTCH1
PAK7
rapge4
slc1a3
st6galnac1(a gene with a unknown function,but thought to add sugars to proteins)
TPH1 rs1800532

Friday 25 July 2008

Genetic atlases

The Allen institue for Brain Science published the Allen Brain Atlas in 2006, which mapped the expression of about 20,000 mouse brain genes.

The Allen institue is now doing an atlas of the expression of about 18,500 genes of the spinal cord.

Sunday 20 July 2008

Parents and grandparents lifestyle effects on future generations

According to epigenetics, what your ancestors eat,drink, smoking habits, exposure to pollutants or obesity etc can affect future generations .

There is evidence that the present diabetes, heart disease and obesity epidemics are partly linked to past generations lifestyle.

Obese pregnant mothers may be causing epigenetic changes in their children.

Smoking father had more obese children, the smoking is believe to change how the chilren's genes are expressed.

A study of a Swedish community who experienced food shortages,the grandchildren lived longer,there was evidence of an epigenetic change.

Forty-plus fathers were more likely to have autistic children,this being possibly epigenetic in nature.

Equinine genes

All white horses are properbly descended from one horse with a defective gene.

Thousands of years ago, humans may have noticed a particular white horse that they protected the horse and breed more white horse.

White horses have a higher risk of getting skin cancer, 75% by the age of 15 have a benign form of melanoma, which can turn malign.

Genetic analysis

75% of Iberian Early Holocene horses had the black allele located on the ASIP gene.
Search Amazon.com for Iberian horses
Researchers believe that those with two copies of  a myostatin-suppressing C version of a particular gene are more likely to win in a 6.5 furlongs race,whereas those with two copies of the T version wre more likely to win in a 13.5 furlongs race.

All thoroughbred  horses in england are descended rom three arabian stallions wheras the female ancestors are either english or irish mares.
Search Amazon.com for horse genetics

Saturday 19 July 2008

Jacob's Legacy;A genetic view of Jewish history

This book combines genetics and biblical history over a period of about 3,000 years.

Possibly mentions the Lemba,who I understand has the same male genetic code as the Cohanim,supposedly descended from Aaron,brother of Moses
Search Amazon.com for jacob's legacy
Search Amazon.com for lemba

Thursday 17 July 2008

How genes affect HIV infection

A mutation in the gene CCL5 accelerates the progression of HIV-1 in those of American European descent.

CCR5 delation is connected withproection against HIV

DARC- found in about 60% of african Americans, appears to slow the the progression of HIV.

Duffy-negativity,common among africans is also believed to increase suspectibility to HIV.

Mitchondrial DNA appears to affect progression towards AIDS.

Thoses with the U5A1 and J haplogroups progressed faster towards AIDS.

Thoses with the H3 haplogroup

Duffy-positive and Duffy-negative

Most africans have the duffy-negative gene(DARC-), because it confers resistance against the malaria parasite.

However,the same genetic variant may well be to blame for the HIV epidemic among africans, because it may be making them more suspectible.

Friday 11 July 2008

Gene Wiki project

Wikipaedia is doing this project using a computer programme to retrieve and collate information from scientific databases.

So far, details of over 8,000 genes are in the project.

genes linked to some cases of CJD

Some cases of CJD(Creuzfeldt-Jakob Disease) are caused by mutations in a gene called Prp.

When mutated,these cause a build up of prions.

Saturday 5 July 2008

Genetic differences between humans and other primates

Humans may be the only mammal that lacks Neu5Gc, having Neu5Ac instead, because of a mutation that disables an enzyme that converts Neu5Ac to Neu5Gc.

Gene may have originated about 2 millionn years ago.

This and other genetic differences may explain susceptibilities to different diseases like diferent types of malaria, arthritis, alzheimer's and multiple sclerosis.

Tuesday 1 July 2008

Y chromosomes journey around the world

At the root of the Y chromosomes tree are the San, followed by Mbuti, then Biaka pygmies, followed by Bantus and west Africans and the youngest y chromosomes are those of Pacific islanders and Tierra de Fuego.

Studies suggest american indians are related to East Siberians.

Genetic origins of Finno-Ugric peoples is in the Pamir area