A version(epsilon4, increases risk up to 12 times) of the APOE gene is associated with alzheimer's.
Sites on a brain protein called tau are linked to alzheimer's, if a tau protein becomes entangled,it can lead to alzheimer's.
Polymorphism called P86L in a gene called CALHMI, in alzheimers' patients,this polymorphism occurs in 40% of such patients, whereas normally the polymorphism occurs in only 20% o the population.
It affects calcium levels in the brain.
The connection is not 100% sure.
Mutation in the PSEN1 and PSEN2 may also be associated with alzheimers'
http://www.alzgene.org/
Pcdh11x variant associated wih alzhimers.
APP mutant;A673V in a homozygous state.
Two copies of a mutation(above?) in APP gene is more likely to lead to Alzheimers'.
Presenilin 1 and 2 are also associated with alzheimers.
Variants of two genes called clusterin(involved in removing rogue proteins) and picalm are associate wih alzheimers.
A variant of the CR1 gene has also been linked with alzheimers.
The ephb2 receptor,a group of tyrosine kinase receptors has been implicated in alzheimer's.
Friday, 18 April 2008
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