The cost of doing a personalised genome may become as low as £50
Companies potentially in the market;
23andme
bionanomatrix
Complete Genomics
deCODE
DNA direct
knome,Cambridge,Massachusetts.
Navigenics
Monday 21 April 2008
Friday 18 April 2008
James watson's genome sequenced
It cost US$1.5 million to produce and was done by 454 life sciences, owned by Roche.
They found over 3 million single nucleotide polymorphisms(SNPs).
They found over 3 million single nucleotide polymorphisms(SNPs).
genes linked to Alzheimer's
A version(epsilon4, increases risk up to 12 times) of the APOE gene is associated with alzheimer's.
Sites on a brain protein called tau are linked to alzheimer's, if a tau protein becomes entangled,it can lead to alzheimer's.
Polymorphism called P86L in a gene called CALHMI, in alzheimers' patients,this polymorphism occurs in 40% of such patients, whereas normally the polymorphism occurs in only 20% o the population.
It affects calcium levels in the brain.
The connection is not 100% sure.
Mutation in the PSEN1 and PSEN2 may also be associated with alzheimers'
http://www.alzgene.org/
Pcdh11x variant associated wih alzhimers.
APP mutant;A673V in a homozygous state.
Two copies of a mutation(above?) in APP gene is more likely to lead to Alzheimers'.
Presenilin 1 and 2 are also associated with alzheimers.
Variants of two genes called clusterin(involved in removing rogue proteins) and picalm are associate wih alzheimers.
A variant of the CR1 gene has also been linked with alzheimers.
The ephb2 receptor,a group of tyrosine kinase receptors has been implicated in alzheimer's.
Sites on a brain protein called tau are linked to alzheimer's, if a tau protein becomes entangled,it can lead to alzheimer's.
Polymorphism called P86L in a gene called CALHMI, in alzheimers' patients,this polymorphism occurs in 40% of such patients, whereas normally the polymorphism occurs in only 20% o the population.
It affects calcium levels in the brain.
The connection is not 100% sure.
Mutation in the PSEN1 and PSEN2 may also be associated with alzheimers'
http://www.alzgene.org/
Pcdh11x variant associated wih alzhimers.
APP mutant;A673V in a homozygous state.
Two copies of a mutation(above?) in APP gene is more likely to lead to Alzheimers'.
Presenilin 1 and 2 are also associated with alzheimers.
Variants of two genes called clusterin(involved in removing rogue proteins) and picalm are associate wih alzheimers.
A variant of the CR1 gene has also been linked with alzheimers.
The ephb2 receptor,a group of tyrosine kinase receptors has been implicated in alzheimer's.
Friday 11 April 2008
Native American DNA found in Oregon Cave
Mitochondrial DNA has been recovered from 14,300 years old fossilised faeces(coprolites) discovered in the Paisley caves in Oregon, USA.
The DNA comes from one of two founding groups of Native American
The DNA comes from one of two founding groups of Native American
Friday 4 April 2008
Genes associated with smoking and nicotine addiction as well as lung cancer
CHRNA3(RS1051730, T allele version increases chances of lung cancer by 30%)
CHRNA5(RS16969968)
CHRNB4
IREB2
LOC123688
PSMA4
These are located in the 15q25(chromosome 15)locus
Located in the 15q24 locus.
RS1317286
RS6495308
The chemicals in cigarette smoke cause one gene mutation for every 15 cigarettes smoked
(Park2 is associated with lung cancer)
CHRNA5(RS16969968)
CHRNB4
IREB2
LOC123688
PSMA4
These are located in the 15q25(chromosome 15)locus
Located in the 15q24 locus.
RS1317286
RS6495308
The chemicals in cigarette smoke cause one gene mutation for every 15 cigarettes smoked
(Park2 is associated with lung cancer)
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