Friday 12 September 2008

genes linked to brain cancer

A mutation in a gene called IDH1 appears in gliolastoma suffers who are 20 years younger than normal glioblastoma suffers.
Mutation(s) produce an amino acid substitation at arg132(R132)

Mutations in the following genes have been associated with glioblastoma;EGFR, MLH1,MSH2, MSH6, NF1(mutations e25-1, e29+1, Q1966, R1513 R1391S),PI(3)K, PMS2, TP53 ,

The APC and beta-catenin gene have been implicated in brain cancer.

Park2 has also been associated with glioblastoma

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